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更新日期：2018-11-04
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Amino Acid Structure
Interactions
Water
Hydrophobic Interaction
van der Waals Interactions and London Dispersion Forces
Hydrogen Bonds
Secondary Structure
Protein Stability
Favorable (Good) Interactions
Unfavorable (Bad) Interactions
Temperature-Sensitive Mutations
Ligand-Binding Specificity
Global Conclusion
MEMBRANE PROTEINS
General Membrane Function
Membrane Composition
Phospholipid Bilayer
Membrane Structure
Posttranslational Modification
Membrane Fluidity
Diffusion in Membranes
Movement of Ions and Molecules Across Membranes
Transport Across Membranes
The Nernst Equation
DNA Structure
DNA Stability
RNA Secondary Structure
Information Metabolism
Directions and Conventions
DNA Replication
Types of DNA Polymerase
Recombination
Regulation of Information Metabolism
Transcription
Regulation of Transcription
Translation
Use of High-Energy Phosphate Bonds During Translation
Restriction Analysis
Gels and Electrophoresis
Blotting
Restriction Fragment-Length Polymorphism
Cloning
Sequencing
Mutagenesis
Polymerase Chain Reaction
Active Site
Transition State
Catalysis
Lock and Key
Induced Fit
Nonproductive Binding
Entropy
Strain and Distortion
Transition-State Stabilization
Transition-State Analogs
Chemical Catalysis
S, P, and E (Substrate, Product, Enzyme)
Amounts and Concentrations
Active Site
Assay
Velocity
Initial Velocity
Mechanism
Little k’s
Michaelis-Menten Equation
Vmax
kcat
Km
Special Points
kcat/Km
Rate Accelerations
Steady-State Approximation
Transformations and Graphs
Inhibition
Allosterism and Cooperativity
The Monod-Wyman-Changeaux Model
Signal Transduction Pathways
Organization
Signals
Receptors
Soluble Receptors
Transmembrane Receptors
Enzyme Coupled Receptors
G-Protein Coupled Receptors
Ion-Channel Coupled Receptors
Second Messengers
Amplifiers
Integrators
Inhibitors
Effect of Arsenate
Lactate or Pyruvate
Function
Location
Molecular Features
Fatty Acid Synthesis Function
Fatty Acid Synthesis Location
Fatty Acid Synthesis Connections
Fatty Acid Synthesis Regulation
Fatty Acid Synthesis ATP Costs (for C)
Fatty Acid Synthesis Equation
Elongation and Desaturation
Triglyceride and Phospholipid Synthesis
-Oxidation of Unsaturated Fatty Acids
-Oxidation of Odd-Chain-Length Fatty Acids
Oxidation and Reduction
The Electron Transport Chain
Connections
Regulation
P/O Ratios
Uncouplers
Inhibitors
Pentose Phosphate Pathway
Glucose
Storage Molecules
Metabolic States and Signals
Insulin
Glucagon
Epinephrine
Secondary Signals
Generalities of Metabolism
Phosphorylation
Glycogen
Metabolic Movements of Glycogen
Fat
Metabolic Movements of Fat
Protein
Metabolic Movements of Protein
Tissue Cooperation
Liver
Muscle
Adipose
Brain
Connection of Storage Pools
Feeding
Fasting
Starvation
Excitement
Interorgan Cycles
Cori Cycle
Alanine Cycle
Ketone Bodies
Urea Cycle
Purine Synthesis
Purine Salvage
Deoxynucleotides
Purine Degradation
Pyrimidine Synthesis
Pyrimidine Salvage
Pyrimidine Degradation
One-Carbon Metabolism
Oxidation States of Carbon
Glucose to Pyruvate
TCA Cycle
Proton: H or HO
Acid
Base
Not All Acids and Bases Are Created Equal
Weak Acids Make Strong Bases (and Vice Versa)
Who Gets the Proton?
Don’t Forget Stoichiometry
Buffers
Henderson-Hasselbalch Equation
Titration Curves
pI—Isoelectric Point
The Bicarbonate Buffer
Imbalance in Blood pH
Acidosis and Alkalosis
